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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMAD6
All Species:
13.64
Human Site:
T174
Identified Species:
25
UniProt:
O43541
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43541
NP_001136333.1
496
53497
T174
L
L
E
Q
E
L
K
T
V
T
Y
S
L
L
K
Chimpanzee
Pan troglodytes
XP_523105
496
53474
T174
L
L
E
Q
E
L
K
T
V
T
Y
S
L
L
K
Rhesus Macaque
Macaca mulatta
XP_001104638
454
49165
R156
L
L
E
A
V
E
S
R
G
G
V
P
G
G
C
Dog
Lupus familis
XP_544737
499
53465
T175
L
L
E
Q
E
L
K
T
V
T
Y
S
L
L
K
Cat
Felis silvestris
Mouse
Mus musculus
O35182
495
53696
T175
L
L
E
Q
E
L
K
T
V
T
Y
S
L
L
K
Rat
Rattus norvegicus
O88406
426
46439
P149
A
S
A
Q
P
A
Q
P
P
S
S
Y
S
L
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516238
280
31765
Chicken
Gallus gallus
Q9W734
431
47806
L149
V
A
R
G
E
L
R
L
G
A
A
R
R
P
P
Frog
Xenopus laevis
NP_001091249
352
38824
V75
A
P
G
L
C
V
M
V
T
R
H
G
P
P
P
Zebra Danio
Brachydanio rerio
Q9I9P9
468
52435
K157
C
E
Y
A
F
N
L
K
K
D
E
V
C
V
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P42003
455
50486
F160
L
V
P
R
H
S
E
F
A
P
G
H
S
M
L
Honey Bee
Apis mellifera
XP_396816
251
28007
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_798238
371
42051
L95
P
H
V
L
C
C
Q
L
F
R
W
P
E
L
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
90.7
94.9
N.A.
93.3
42.5
N.A.
44.3
67.5
51
23.7
N.A.
22.5
29.2
N.A.
38.9
Protein Similarity:
100
99.4
90.9
95.7
N.A.
94.3
54.2
N.A.
49.7
73.1
58
39.9
N.A.
38.9
34.4
N.A.
50.2
P-Site Identity:
100
100
20
100
N.A.
100
13.3
N.A.
0
13.3
0
0
N.A.
6.6
0
N.A.
13.3
P-Site Similarity:
100
100
20
100
N.A.
100
26.6
N.A.
0
26.6
13.3
6.6
N.A.
33.3
0
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
16
8
8
16
0
8
0
0
8
8
8
0
0
0
0
% A
% Cys:
8
0
0
0
16
8
0
0
0
0
0
0
8
0
8
% C
% Asp:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% D
% Glu:
0
8
39
0
39
8
8
0
0
0
8
0
8
0
0
% E
% Phe:
0
0
0
0
8
0
0
8
8
0
0
0
0
0
0
% F
% Gly:
0
0
8
8
0
0
0
0
16
8
8
8
8
8
0
% G
% His:
0
8
0
0
8
0
0
0
0
0
8
8
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
31
8
8
0
0
0
0
0
39
% K
% Leu:
47
39
0
16
0
39
8
16
0
0
0
0
31
47
8
% L
% Met:
0
0
0
0
0
0
8
0
0
0
0
0
0
8
0
% M
% Asn:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
8
% N
% Pro:
8
8
8
0
8
0
0
8
8
8
0
16
8
16
24
% P
% Gln:
0
0
0
39
0
0
16
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
8
8
0
0
8
8
0
16
0
8
8
0
0
% R
% Ser:
0
8
0
0
0
8
8
0
0
8
8
31
16
0
0
% S
% Thr:
0
0
0
0
0
0
0
31
8
31
0
0
0
0
0
% T
% Val:
8
8
8
0
8
8
0
8
31
0
8
8
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% W
% Tyr:
0
0
8
0
0
0
0
0
0
0
31
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _